Understanding patient experience from online medium

Improving patient experience at hospitals leads to better health outcomes. To improve this, we must first understand and interpret patients' written feedback. Patient-generated texts such as patient reviews found on RateMD, or online health forums found on WebMD are venues where patients post about their experiences. Due to the massive amounts of patient-generated texts that exist online, an automated approach to identifying the topics from patient experience taxonomy is the only realistic option to analyze these texts. However, not only is there a lack of annotated taxonomy on these media, but also word usage is colloquial, making it challenging to apply standardized NLP technique to identify the topics that are present in the patient-generated texts. Furthermore, patients may describe multiple topics in the patient-generated texts which drastically increases the complexity of the task. In this thesis, we address the challenges in comprehensively and automatically understanding the patient experience from patient-generated texts. We first built a set of rich semantic features to represent the corpus which helps capture meanings that may not typically be captured by the bag-of-words (BOW) model. Unlike the BOW model, semantic feature representation captures the context and in-depth meaning behind each word in the corpus. To the best of our knowledge, no existing work in understanding patient experience from patient-generated texts delves into which semantic features help capture the characteristics of the corpus. Furthermore, patients generally talk about multiple topics when they write in patient-generated texts, and these are frequently interdependent of each other. There are two types of topic interdependencies, those that are semantically similar, and those that are not. We built a constraint-based deep neural network classifier to capture the two types of topic interdependencies and empirically show the classification performance improvement over the baseline approaches. Past research has also indicated that patient experiences differ depending on patient segments [1-4]. The segments can be based on demographics, for instance, by race, gender, or geographical location. Similarly, the segments can be based on health status, for example, whether or not the patient is taking medication, whether or not the patient has a particular disease, or whether or not the patient is readmitted to the hospital. To better understand patient experiences, we built an automated approach to identify patient segments with a focus on whether the person has stopped taking the medication or not. The technique used to identify the patient segment is general enough that we envision the approach to be applicable to other types of patient segments. With a comprehensive understanding of patient experiences, we envision an application system where clinicians can directly read the most relevant patient-generated texts that pertain to their interest. The system can capture topics from patient experience taxonomy that is of interest to each clinician or designated expert, and we believe the system is one of many approaches that can ultimately help improve the patient experience

Tau functions as Widom constants

We define a tau function for a generic Riemann-Hilbert problem posed on a union of non-intersecting smooth closed curves with jump matrices analytic in their neighborhood. The tau function depends on parameters of the jumps and is expressed as the Fredholm determinant of an integral operator with block integrable kernel constructed in terms of elementary parametrices. Its logarithmic derivatives with respect to parameters are given by contour integrals involving these parametrices and the solution of the Riemann-Hilbert problem. In the case of one circle, the tau function coincides with Widom's determinant arising in the asymptotics of block Toeplitz matrices. Our construction gives the Jimbo-Miwa-Ueno tau function for Riemann-Hilbert problems of isomonodromic origin (Painlev\'e VI, V, III, Garnier system, etc) and the Sato-Segal-Wilson tau function for integrable hierarchies such as Gelfand-Dickey and Drinfeld-Sokolov.Comment: 26 pages, 6 figure

Real-Time Monitoring of Cancer Cells in Live Mouse Bone Marrow

Disseminated tumor cells in the bone marrow environment are the main cause of systemic metastasis after curative treatment for major solid tumors. However, the detailed biological processes of tumor biology in bone marrow have not been well defined in a real-time manner, because of a lack of a proper in vivo experimental model thereof. In this study, we established intravital imaging models of the bone marrow environment to enable real-time observation of cancer cells in the bone marrow. Using these novel imaging models of intact bone marrow and transplanted bone marrow of mice, respectively, via two-photon microscopy, we could first successfully track and analyze both the distribution and the phenotype of cancer cells in bone marrow of live mouse. Therefore, these novel in vivo imaging models for the bone marrow would provide a valuable tool to identify the biologic processes of cancer cells in a real-time manner in a live animal model

Genetic Parameters of Reproductive and Meat Quality Traits in Korean Berkshire Pigs

Genetic parameters of Berkshire pigs for reproduction, carcass and meat quality traits were estimated using the records from a breeding farm in Korea. For reproduction traits, 2,457 records of the total number of piglets born (TNB) and the number of piglets born alive (NBA) from 781 sows and 53 sires were used. For two carcass traits which are carcass weight (CW) and backfat thickness (BF) and for 10 meat quality traits which are pH value after 45 minutes (pH45m), pH value after 24 hours (pH24h), lightness in meat color (LMC), redness in meat color (RMC), yellowness in meat color (YMC), moisture holding capacity (MHC), drip loss (DL), cooking loss (CL), fat content (FC), and shear force value (SH), 1,942 pig records were used to estimate genetic parameters. The genetic parameters for each trait were estimated using VCE program with animal model. Heritability estimates for reproduction traits TNB and NBA were 0.07 and 0.06, respectively, for carcass traits CW and BF were 0.37 and 0.57, respectively and for meat traits pH45m, pH24h, LMC, RMC, YMC, MHC, DL, CL, FC, and SH were 0.48, 0.15, 0.19, 0.36, 0.28, 0.21, 0.33, 0.45, 0.43, and 0.39, respectively. The estimate for genetic correlation coefficient between CW and BF was 0.27. The Genetic correlation between pH24h and meat color traits were in the range of −0.51 to −0.33 and between pH24h and DL and SH were −0.41 and −0.32, respectively. The estimates for genetic correlation coefficients between reproductive and meat quality traits were very low or zero. However, the estimates for genetic correlation coefficients between reproductive traits and drip and cooking loss were in the range of 0.12 to 0.17 and −0.14 to −0.12, respectively. As the estimated heritability of meat quality traits showed medium to high heritability, these traits may be applicable for the genetic improvement by continuous measurement. However, since some of the meat quality traits showed negative genetic correlations with carcass traits, an appropriate breeding scheme is required that carefully considers the complexity of genetic parameters and applicability of data